Prednisone is a synthetic steroid hormone meant to work similarly to the naturally-occurring hormone cortisol. ... Methylprednisolone may induce problems with menstruation in women who take the medicine 1. My face turns a little red-- I look a little flushed. Red skin syndrome (RSS) is caused by long-term or excessive use of topical steroid drugs. My face felt like it was on fire and my whole head was red. Flushing causes the skin to become hot and the face will turn red. The phase IV clinical study is created by eHealthMe based on reports of 399,836 people who have side effects when taking Prednisone from the FDA, and is updated regularly. What is Prednisone? 31 years experience Internal Medicine. Face turning red and burning after starting prednisone. LBJ. See how to counteract eight common prednisone side effects, including fluid retention, and learn how proper prednisone … Find out more about the symptoms and causes. It can alter the menstrual cycle, causing periods to become irregular. Dr. Gebrehana Zebro (formerly Woldegiorgis) answered. Is this something that happens with steroids? Difficulty breathing is a common symptom of an allergic reaction to prednisone. You should refer to the prescribing information for methylprednisolone for a complete list of interactions. Is this from the steroids? prednisone red face. Raised red areas of skin, commonly known as hives, may also develop. Swelling of the face, lips, or tongue are common symptoms of an allergy. I feel much better from yesterday, with a bit more pep today, and the red face isnt causing any discomfort, but i feel it there. “The picture on the left is my senior homecoming after being on prednisone for several months. but now my face is extremely red and i'm very hot. Skin blushing/flushing is found among people who take Prednisone, especially for people who are female, 60+ old, have been taking the drug for < 1 month. A 43-year-old female asked: i just weaned down from prednisone and i'm off of the steroid. I have been off the prednisone for 2 days but am still experiencing the symptoms. My skin feels hot to the touch on my face and has a burning hot sensation. I had serious weight gain and ‘moon face!’ The picture on the right is the following summer after being off of prednisone and getting back to my normal, healthy weight.” — Brianna D. Note that this list is not all-inclusive and includes only common medications that may interact with methylprednisolone. 8 Prednisone Side Effects + How to Minimize Them. i never had any side effects. It seems to have swollen just a tad since this morning. About a week into taking the prednisone, I developed a very hot and burning face and neck. It also can cause a condition known as amenorrhea, which means periods suddenly stop without pregnancy occurring. Support Forums > ... 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